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目的 :探讨中性粒细胞CD64对慢性细菌性前列腺炎诊断、病情疗程、预后分析的价值。方法 :慢性细菌性前列腺炎患者60例在就诊初期和对症用药1、4周,采空腹静脉血和前列腺液,应用流式细胞仪定量测定前列腺液中性粒细胞CD64表达,同期进行外周血CRP测定。结果:慢性细菌性前列腺炎治疗4周组CD64表达量显著低于就诊初期和治疗1周,差异有统计学意义(P<0.05)。当CD64最佳临界值为3 096.48分子数/细胞时,中性粒细胞CD64对慢性细菌性前列腺炎诊断的敏感性91%,特异性73.7%,均优于CRP。结论:中性粒细胞CD64可作为慢性细菌性前列腺炎早期诊断的定量标准,是判断病情的可靠指标。
Objective: To investigate the value of neutrophil CD64 in diagnosis, course of disease and prognosis of chronic bacterial prostatitis. Methods: Sixty patients with chronic bacterial prostatitis were treated with fasting venous blood and prostatic fluid in the initial and symptomatic treatment for 1, 4 weeks. The expression of CD64 in prostatic fluid was quantified by flow cytometry, Determination. Results: The expression of CD64 in the group of chronic bacterial prostatitis for 4 weeks was significantly lower than that of the initial stage of treatment and 1 week of treatment, the difference was statistically significant (P <0.05). When the optimal cutoff value of CD64 was 3 096.48 molecules / cell, the sensitivity and specificity of neutrophil CD64 to chronic bacterial prostatitis were 91% and 73.7%, respectively, which were better than CRP. Conclusion: Neutrophil CD64 can be used as a quantitative standard for the early diagnosis of chronic bacterial prostatitis and is a reliable indicator of the disease.