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胎盘早剥是是妊娠晚期的严重并发症之一,处理不当可危及母儿生命。胎盘的缺血性损伤被认为是胎盘早剥的最初原因。胎盘缺血性损伤导致了滋养细胞侵袭能力的改变及子宫螺旋小动脉发生的重塑障碍,胎盘缺血、缺氧后释放各种细胞因子造成蜕膜坏死、血管破裂、出血,而出血导致底蜕膜和胎盘之间形成撕裂和分离,进而造成蜕膜板和胎盘的分离。进一步造成更多的血管破裂、动脉出血和胎盘后血肿,最后导致胎盘早剥的发生。
Placental abruption is one of the serious complications of late pregnancy, improper handling can endanger the mother’s life. Ischemic placental damage is considered to be the earliest cause of placental abruption. Ischemic placental injury led to changes in the ability of trophoblast invasion and remodeling of uterine spiral arterioles, placental ischemia, hypoxia after the release of various cytokines caused by decidual necrosis, rupture of blood vessels, bleeding, and bleeding led to the end Decidual and placental tear and separation between the formation, and then cause the separation of decidualized plate and placenta. Further cause more rupture of blood vessels, arterial hemorrhage and placental hematoma, finally leading to the occurrence of placental abruption.