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目的探讨生殖免疫自身抗体六项指标在妇科不孕不育诊断中的临床价值。方法采用酶联免疫吸附测定(ELISA间接法)测定血清抗精子抗体(AsAb),抗心磷脂抗体(ACA),抗卵巢抗体(AOA),抗子宫内膜抗体(EMAb),抗透明带抗体(AZ-PA),抗绒毛膜促性腺激素抗体(AhCGA)等六项免疫指标,对289例妇科不孕不育病人的免疫状态进行检测。并与50例健康妇女作对照。用多元分析法对六项免疫指标的相关性及妇科不孕不育诊断性能加以评估。结果妇科不孕不育患者的生殖状况与其六项自身抗体的阳性率密切相关,其阳性率:AsAb 39.1%(113/289)、ACA 22.49%(65/289)、AOA 14.18%(41/289)、EMAb32.87%(95/289)、AZPA 6.57%(19/289)、AhCGAb 13.14%(38/289)。结论六项指标均可单独反映不孕不育病人的免疫状态,有助于鉴别不孕不育的性质、判断不孕不育的程度及预后。
Objective To investigate the clinical value of six indicators of reproductive immune autoantibodies in the diagnosis of infertility of gynecology. Methods Serum antisperm antibody (AsAb), anti-cardiolipin antibody (ACA), anti-ovarian antibody (AOA), anti-endometrial antibody (EMAb), anti-zona pellucida antibody AZ-PA) and anti-chorionic gonadotropin antibody (AhCGA) were used to detect the immune status of 289 gynecological infertility patients. And compared with 50 healthy women. Multivariate analysis of the six immune indicators and gynecological infertility diagnostic performance to be assessed. Results The reproductive status of gynecological infertility patients was closely related to the positive rate of six autoantibodies. The positive rates of AsAbs were 39.1% (113/289), 22.49% (65/289), 14.18% (41/289) ), EMAb 32.87% (95/289), AZPA 6.57% (19/289) and AhCGAb 13.14% (38/289). Conclusion All six indexes can reflect the immune status of infertility patients individually, help to identify the nature of infertility and determine the degree and prognosis of infertility.