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药源性间质性肺疾病(DI-ILD)是最常见的药源性肺部疾病,目前已知多种药物可导致间质性肺疾病,其发病机制与药物引起的变态反应和直接细胞毒性作用有关。此类疾病临床症状、影像学及组织病理学表现均无特异性,临床诊断DI-ILD需根据病史(用药史)、临床特点、胸部影像学、组织病理学改变及治疗效果。临床疑诊DI-ILD时应立刻停药并应用糖皮质激素。若及时干预,预后良好。
Drug-induced interstitial lung disease (DI-ILD) is the most common drug-induced pulmonary disease, a variety of drugs are known to cause interstitial lung disease, its pathogenesis and drug-induced allergies and direct cytotoxicity Relevant role. The clinical symptoms, imaging and histopathological manifestations of these diseases are nonspecific. Clinical diagnosis of DI-ILD should be based on medical history, clinical features, chest imaging, histopathological changes and therapeutic effect. Clinically suspected DI-ILD should be discontinued immediately and the application of glucocorticoid. If timely intervention, the prognosis is good.