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为了审估FAB分类法的再现性和临床意义、三名观察者用双盲法各自复习了233例儿童急性白血病在确诊时所做的骨髓涂片、在170例急性淋巴细胞型白血病(ALL)的病例中、三者一致同意亚型分类者(L_1、L_2和L_3型)占69.4％。两者意见基本一致者占86.8％。血液学缓解后的12个月中,在L_1型的61例患儿中有57例(93.4％)、与L_2型的20例患儿中有14例(70％)相比、仍存在着统计学差异(P<0.05)。这两组在缓解后24个月或36个月相比,则没有统计学差异。7岁以上的儿童L_2型发病率升高(P<0.05)。我们的结论是虽然对各自所用的分类法标准的解释差异很大,但都同意原始细胞形态学对预后的判定可能是有用的因素。
To assess the reproducibility and clinical significance of the FAB classification, three observers reviewed the bone marrow smears of 233 children with acute leukemia at the time of diagnosis by double-blind method. In 170 cases of acute lymphoblastic leukemia (ALL) Of the cases, the three agreed that the subtypes (L_1, L_2 and L_3 type) accounted for 69.4%. The two basically the same opinion accounted for 86.8%. In the 12 months after hematologic remission, 57 (93.4%) of the 61 children with L_1 and 14 (70%) of the 20 children with L_2 remained statistic Learning difference (P <0.05). There was no statistical difference between these two groups at 24 months or 36 months after remission. The incidence of L 2 type in children over 7 years old increased (P <0.05). Our conclusion is that although the interpretations of the taxonomic criteria used vary widely, it is agreed that the determination of prognosis by blast cell morphology may be a useful factor.