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目的 探讨脑梗死病人垂体 性腺轴功能变化的规律 ,为小剂量雌激素补充疗法提供理论依据。方法 采用放射免疫法 ,检测血清促卵泡素 (FSH)、黄体生成素 (LH)、雌二醇 (E2 )、催乳素 (PRL)浓度。绝经期脑梗死病人 6 8例 ,皮层动脉梗死 (CAIG) 2 6例 ,穿通动脉腔隙性梗死 (PAIG) 4 2例 ,健康对照组 2 6例。结果 脑梗死组血清FSH、LH及E2 显著低于正常组 (P <0 .0 1) ,PRL轻度升高 (P <0 .0 5 ) ;CAIG组和PAIG组血清FSH、LH、及PRL比较差异无显著性 (P >0 .0 5 ) ,CAIG组E2 轻度升高 (P <0 .0 5 )。结论 脑梗死病人垂体 性腺轴功能显著减退 ,不受脑梗死部位及范围的影响 ,小剂量补充雌激素将有可能预防脑梗死
Objective To investigate the changes of pituitary gland axis function in patients with cerebral infarction and to provide a theoretical basis for low dose estrogen replacement therapy. Methods Serum FSH, LH, E2 and PRL were measured by radioimmunoassay. There were 68 cases of menopausal cerebral infarction, 26 cases of cerebral infarction (CAIG), 42 cases of lacunar infarction (PAIG) and 26 cases of healthy control group. Results Serum levels of FSH, LH and E2 in cerebral infarction group were significantly lower than those in normal group (P <0.01), and PRL were slightly increased (P <0.05); serum FSH, LH and PRL in CAIG group and PAIG group There was no significant difference between the two groups (P> 0.05), while E2 in CAIG group increased slightly (P <0.05). Conclusions The function of pituitary gland axis in patients with cerebral infarction is significantly reduced, not affected by the location and extent of cerebral infarction. Small doses of estrogen replacement may prevent cerebral infarction