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microRNA是一种非编码蛋白的RNA,其长度为18～22 nt。microRNA在生物的生长、发育、分化、增殖、凋亡等多种生物学过程中发挥着重要作用。近来的研究发现microRNA在癌症的发生发展和转移过程中也起着重要的作用,有些已经成为治疗癌症的靶向基因。肺癌是目前中国乃至世界范围内主要恶性疾病之一,迄今为止,肺癌的发病机制尚未完全清楚,在其发生发展过程中有多种microRNA参与并起着重要作用。本文就microRNA与肺癌的相关性研究新进展做简要的综述。
microRNA is a non-coding protein RNA of 18-22 nt in length. MicroRNA plays an important role in a variety of biological processes such as growth, development, differentiation, proliferation and apoptosis of organisms. Recent studies have found that microRNAs also play an important role in the development and metastasis of cancer, and some of them have become target genes for the treatment of cancer. Lung cancer is one of the major malignant diseases in China and the world at present. Up to now, the pathogenesis of lung cancer has not been fully understood. Many microRNAs play an important role in the development and progression of lung cancer. This article reviews the recent progress in the study of the correlation between microRNA and lung cancer.