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胃粘膜上皮化生(肠化)在胃癌、胃溃疡、十二指肠溃疡和萎缩性胃炎中均不少见。肠化在这些病理过程中出现的意义和功能如何,较长时期来一直是许多学者重视的问题。Morson(1955)指出某些胃癌可能起源于肠化,Lauren(1965)提出了著名的肠型和弥漫型(后者也被一些学者称为胃型)胃癌的分类,认为前者来源于肠化。近年来,许多学者都指出,视一切肠化为癌前病变是不恰当的。一些学者通过组织化学研究把肠化分为几种亚型,认为其中某些亚型是反应性改变,而另一些才与胃癌有关,可能为癌前病变。本文试图通过肠化的粘液组织化学研究以探寻肠化类型与胃癌的关系。
Gastric epithelial metaplasia (intestinal metaplasia) is not uncommon in gastric cancer, gastric ulcer, duodenal ulcer, and atrophic gastritis. The significance and function of intestinal metastasis in these pathological processes has been a problem that many scholars have been paying attention to for a long period of time. Morson (1955) pointed out that some gastric cancers may originate from intestinal metaplasia. Lauren (1965) proposed the famous intestinal type and diffuse type (the latter also known as stomach type by some scholars) classification of gastric cancer, and the former is considered to be derived from intestinal metaplasia. In recent years, many scholars have pointed out that it is not appropriate to regard all intestinal metastases as precancerous lesions. Some scholars have divided intestinal metaplasia into several subtypes through histochemical studies. Some of these subtypes are thought to be reactive, while others are related to gastric cancer and may be precancerous lesions. This article attempts to explore the relationship between the type of intestinal metastasis and gastric cancer through intestinal mucin histochemistry.