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目的研究探讨钙拮抗剂治疗冠心病心绞痛的临床疗效。方法将我院收治的140例冠心病心绞痛患者随机分为两组,即氨氯地平组和硝苯地平组,分别进行氨氯地平和硝苯地平的治疗,治疗中监测治疗效果。结果氨氯地平组和硝苯地平组的总有效率分别为95.71%和70.00%(χ2=16.2931,P<0.05),即氨氯地平药物治疗冠心病心绞痛的效果好于硝苯地平组。氨氯地平组和硝苯地平组中,稳定性冠心病心绞痛与不稳定心绞痛相比较,结果分别为(χ2=3.8961,P<0.05),(χ2=12.9975,P<0.05),即氨氯地平对稳定性冠心病心绞痛效果更好,硝苯地平对不稳定性冠心病心绞痛效果更好。两药均无不良反应出现。结论氨氯地平的对冠心病心绞痛的总体治疗效果更好,但更适于治疗稳定性冠心病心绞痛,而硝苯地平更适于治疗不稳定性冠心病心绞痛。临床上应根据患者的实际选取药物。
Objective To study the clinical efficacy of calcium antagonists in the treatment of angina pectoris. Methods A total of 140 patients with coronary heart disease and angina pectoris admitted to our hospital were randomly divided into two groups, namely amlodipine group and nifedipine group. The patients were treated with amlodipine and nifedipine respectively. The therapeutic effect was monitored during the treatment. Results The total effective rates of amlodipine and nifedipine groups were 95.71% and 70.00%, respectively (χ2 = 16.2931, P <0.05), that is, the effect of amlodipine on angina pectoris was better than nifedipine group. Amlodipine group and nifedipine group, stable angina pectoris and unstable angina pectoris, the results were (χ2 = 3.8961, P <0.05), (χ2 = 12.9975, P <0.05), that is, amlodipine Coronary heart disease on the stability of angina better, nifedipine on unstable angina pectoris better. No adverse reactions to both drugs appear. Conclusion Amlodipine has a better overall curative effect on angina pectoris, but it is more suitable for the treatment of stable angina pectoris, while nifedipine is more suitable for the treatment of unstable angina pectoris. Clinic should be based on the actual selection of patients with drugs.