论文部分内容阅读
硫酸镍多用于金属镀镍工业或作为实验试剂。本文报导其毒性作用。试验用40只大鼠,以50％硫酸镍水溶液灌胃,测得LD_(60)为500毫克/公斤,属中等毒性物质。大鼠在灌胃后30分钟,直肠温度降低,死亡时出现多涎、痉挛。肝、肾发生营养不良性病变。蓄积作用的研究。用30只大鼠,以1/5LD_(60)剂量(100毫克/公斤)的硫酸镍给大鼠灌胃,连续20天,在第21天给予500毫克/公斤。大鼠无死亡,表明其对硫酸镍有耐受性。但血液胆碱酯酶活性明显
Nickel sulfate is mostly used in the nickel metal industry or as an experimental reagent. This article reports its toxic effects. In the experiment, 40 rats were orally administered with 50% nickel sulfate aqueous solution, and LD_ (60) was 500 mg / kg, which was a moderately toxic substance. Rats in the gavage 30 minutes, the rectal temperature decreased, the occurrence of multiple salivation, spasm. Liver, kidney malnutrition occurs. Accumulation of the role of research. Rats were gavaged with 30 rats at a dose of 1/5 LD_ (60) (100 mg / kg) for 20 consecutive days and 500 mg / kg on the 21st day. None of the rats died, indicating their tolerance to nickel sulfate. However, blood cholinesterase activity is obvious