牛角瓜(Calotropis gigantea L.Dryander)属萝藦科,国外产于非洲、伊朗、阿拉伯及印度等地,在苏丹古时作箭毒用。Hesse等从其乳汁中提出calotropin(C_(29)H_(40)O_9)等3种強心甙。陈克恢等亦从其中分离出calotropin等重要成分,并指出这些強心甙有洋地黃样作用,calotropin的效价接近ouabain,以猫法測定,前者为0.111毫克/公斤,后者为0.116毫克/公斤。本品在我国西南亦有分布。中国科学院昆明植物研究所周俊等曾做过化学研究,其药理工作国內尚未見到报告,因此作者进行了这方面的初步研究。实驗材料系周俊所 Calotropis gigantea L.Dryander is a radish family, which is produced in foreign countries in Africa, Iran, Arabia and India, and used as a poison in ancient Sudan. Hesse et al proposed three cardiac glycosides calotropin (C_ (29) H_ (40) O_9) from their milk. Chen Ke-Hui et al also isolated important components such as calotropin from them and pointed out that these cardiac glycosides have digitalis-like effects. The potency of calotropin is close to ouabain, measured by cat method, the former is 0.111 mg / kg and the latter is 0.116 mg / kg . This product is also distributed in southwest China. Zhou Jun, Kunming Institute of Botany, Chinese Academy of Sciences, who had done chemical research, the pharmacological work has not yet seen the domestic report, so the author conducted a preliminary study in this regard. Experimental materials Department of Zhou Jun