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目的探讨黏液纤维肉瘤的临床病理特点及其鉴别诊断。方法采用光镜观察结合临床资料,对2例黏液纤维肉瘤进行临床病理分析,均行免疫组织化学标记。结果2例患者均因局部缓慢增大的无痛性包块就诊,发生于左胸壁及右前臂。镜下,肿瘤主要由梭形细胞和星形细胞构成,部分病例内可见多泡状细胞和核深染的多形性细胞,基质呈显著黏液样。免疫组织化学标记显示,2例瘤细胞均表达vimentin,1例表达CD34,其中1例复发2次。结论黏液纤维肉瘤为一侵袭性较强的软组织肉瘤,易发生局部复发,宜采取以手术切除为主的综合性治疗。
Objective To investigate the clinicopathological features and differential diagnosis of mucinous fibrosarcoma. Methods The clinical data of 2 cases of mucinous fibrosarcoma were observed by light microscopy combined with clinical data. Immunohistochemistry was performed on the specimens. Results Both of the two patients were treated with painless masses with slowly increasing local mass. They occurred in the left chest wall and the right forearm. Microscopically, the tumor mainly consists of spindle cells and astrocytes. In some cases, many bubbling cells and nucleated cells were found, and the stroma was markedly mucoid. Immunohistochemical staining showed that vimentin was expressed in both of the tumor cells and CD34 in 1 case, of which 1 case relapsed twice. Conclusion Myxofibrosarcoma is a highly invasive soft tissue sarcoma, prone to local recurrence, it is appropriate to take a comprehensive surgical treatment.