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目的 :了解硫酸吗啡控释片的不良反应 ,为临床合理用药提供依据。方法 :对兰州军区总医院肿瘤科 5 7例使用硫酸吗啡缓释片治疗晚期癌症患者不良反应进行系统监察 ,并进行分析。结果 :出现恶心 3 5 .1% ,呕吐 19.3 % ,便秘2 8.0 % ,头昏嗜睡 2 2 .8% ,排尿困难 14 .0 % ,另有 2例出现欣快感 ,未见其他严重的不良反应。结论 :药物不良反应的发生与用药剂量无明显关系而与用药总量有一定关系。
Objective: To understand the adverse reactions of morphine sulfate controlled-release tablets and provide the basis for clinical rational drug use. Methods: Fifty-seven patients with cancer in Lanzhou Military Region General Hospital were treated with morphine sulfate sustained-release tablets in the treatment of advanced cancer. The adverse reactions were systematically monitored and analyzed. Results: nausea 35.1%, vomiting 19.3%, constipation 2 8.0%, drowsiness drowsiness 22.8%, dysuria 14. 0%, and another 2 cases euphoria, no other serious adverse reactions . Conclusion: The incidence of adverse drug reactions does not have a significant relationship with the dose and the total amount of medication has a certain relationship.