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目的:探讨免疫组化在肺小细胞癌(SCLC)和肺非小细胞癌(NSCLC)鉴别诊断中的作用。方法:选择2014年4月至2016年3月34例嘉应学院医学院附属医院收治的肺癌患者进行免疫组化检测,比较SCLC和NSCLC的免疫组化标记物阳性表达率。结果:34例肺癌患者经免疫组化检查,有SCLC患者15例,NSCLC19例。神经细胞黏附分子(CD56)、突触素(Syn)、甲状腺转录因子-1(TTF-1)在SCLC中的阳性表达率明显更高(P<0.05),而细胞角蛋白5/6(CK5/6)、细胞角蛋白14(CK14)、肌上皮标记物P63、细胞角蛋白7(CK7)以及天冬氨酸蛋白酶(Napsin A)则在NSCLC中的阳性表达率明显更高(P<0.05)。结论:采取免疫组化检查可对SCLC、NSCLC进行有效鉴别诊断。
Objective: To investigate the role of immunohistochemistry in the differential diagnosis of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Methods: From April 2014 to March 2016, 34 patients with lung cancer admitted to Affiliated Hospital of Jiaying University Medical College were selected for immunohistochemistry. The positive rate of immunohistochemistry in SCLC and NSCLC was compared. Results: 34 cases of lung cancer by immunohistochemistry, there were 15 cases of SCLC, 19 cases of NSCLC. The positive rates of CD56, Syn and TTF-1 in SCLC were significantly higher (P <0.05), while those of cytokeratin 5/6 (CK5 / 6), cytokeratin 14 (CK14), myoepithelial marker P63, cytokeratin 7 (CK7) and Napsin A were significantly higher in NSCLC (P <0.05 ). Conclusion: The immunohistochemical examination of SCLC, NSCLC effective differential diagnosis.