肾小球硬化是多种肾小球疾病发展的最终结局，也是肾功能衰竭的主要病理基础。早期预测并采取措施阻止其硬化的发生和进展，是当今肾脏病防治的重要课题。近年来，随着分子生物学研究的深入，许多实验研究发现转化生长因子β（transform-inggrowthfactorβ，TGF－β）在细胞外 Glomerulosclerosis is the culmination of many glomerular diseases and is the primary pathological basis of renal failure. Early prediction and take measures to prevent the occurrence and progression of sclerosis is an important issue in the prevention and treatment of renal disease. In recent years, with the deepening of molecular biology research, many experimental studies have found that transforming growth factor β (TGF-β)