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目的探讨分析急性早幼粒细胞白血病患者的临床资料及其治疗结果。方法对2008年10月-2012年10月间我院收治的32例APL患者的临床资料进行回顾性分析,诱导治疗采用维甲酸(ATRA)联合三氧化二砷(As203),缓解后常规剂量As203加DA、MA或HA的化疗方案,每2个月1次,15d/次。结果诱导缓解率达90.2%。获得完全缓解的平均时间为(30.3±4.2)d,3例诱导失败出现复发,2例死于脏器功能衰竭,1例死于颅内出血。结论 ATRA联合As203治疗APL可获得较好的临床疗效。
Objective To investigate the clinical data of patients with acute promyelocytic leukemia and its treatment outcome. Methods The clinical data of 32 patients with APL treated in our hospital from October 2008 to October 2012 were analyzed retrospectively. ATRA combined with As203, MA or HA chemotherapy regimen, once every 2 months, 15d / time. Results induction remission rate of 90.2%. The mean time to complete remission was (30.3 ± 4.2) days. Three patients relapsed after induction of failure, two died of organ failure, and one died of intracranial hemorrhage. Conclusion ATRA combined with As203 APL can achieve better clinical efficacy.