房室模型作为药物动力学参数估算普遍使用的方法已沿用多年,但在应用中还存在不少问题,由于常有一个以上的模型与数据相吻合,所以往往可能武断地确定为某一模型,对于参数的估计也常可能带入操作者主观的因素。近年来人们把统计矩的方法引入药物动力学的计算,它不需要预先设定药物在体内的配置属何种模型,只要药物是线性 Atrioventricular model as a commonly used method of pharmacokinetic parameter estimation has been used for many years, but there are still many problems in the application. Since more than one model is often consistent with the data, it may often be arbitrarily determined as a model, It is also often possible to introduce operator subjective factors in the estimation of parameters. In recent years, people introduced the method of statistical moment into the calculation of pharmacokinetics. It does not need to pre-set the model of the drug in the body configuration, as long as the drug is linear