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目的探讨N-端脑钠肽前体在慢性阻塞性肺疾病(COPD)中的变化及其意义。方法117例确诊为COPD患者,分为单纯COPD组和COPD合并肺心病组,用电化学发光法测定血浆NT-ProB-NP并比较其差异。结果COPD合并肺心病组NT-ProBNP水平明显高于单纯COPD组,且NT-ProBNP水平在轻、中、重度肺动脉高压组间差异有统计学意义(P<0.05);NT-ProBNP与肺动脉收缩压、主肺动脉宽度、右心室前壁厚度、右心室舒张末内径有良好的相关性。结论血浆NT-ProBNP浓度能较好地反映COPD患者的肺动脉高压情况及右心室功能状态。
Objective To investigate the changes of N-terminal pro-brain natriuretic peptide in chronic obstructive pulmonary disease (COPD) and its significance. Methods A total of 117 patients diagnosed as COPD were divided into simple COPD group and COPD combined with pulmonary heart disease group. Electro-chemiluminescence was used to determine plasma NT-ProB-NP and their differences were compared. Results The NT-ProBNP level in patients with COPD complicated with pulmonary heart disease was significantly higher than that in patients with COPD alone, and the NT-ProBNP level was significantly different between mild, moderate and severe pulmonary hypertension group (P <0.05). NT-ProBNP and pulmonary artery systolic pressure , The width of the main pulmonary artery, the anterior wall thickness of the right ventricle and the end-diastolic diameter of the right ventricle. Conclusion The plasma concentration of NT-ProBNP can better reflect the pulmonary hypertension and right ventricular function in COPD patients.