采用等温滴定量热仪(isothermal titration calorimetry,ITC)对鞣制条件下,溶液中Cr2(SO4)3与胶原间的相互作用进行了研究。结果表明:在试验所用的胶原稀溶液中,胶原与Cr2(SO4)3之间的作用产生了一定的热量变化,但由于变化太小,无法拟合出有价值的信息。这个热量的变化可能是由Cr3+与胶原羧基之间的络合产生的,也有可能是其它的作用引起的,如Cr2(SO4)3的盐效应。关于溶液中Cr2(SO4)3与胶原的作用机理,还有待进一步的研究。 The interaction between Cr2 (SO4) 3 and collagen in solution was studied under the condition of tanning using isothermal titration calorimetry (ITC). The results show that there is a certain caloric change in the effect of collagen and Cr2 (SO4) 3 in the dilute solution of collagen used in the experiment, but because the change is too small, no valuable information can be fitted. This heat change may be caused by the complexation of Cr3 + with the carboxyl groups of the collagen and may also be caused by other effects such as the salt effect of Cr2 (SO4) 3. The mechanism of action of Cr2 (SO4) 3 and collagen in solution remains to be further studied.