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腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一种高度保守的丝氨酸/苏氨酸蛋白激酶,为真核细胞内的能量感受器。研究表明:AMPK可以通过抑制NF-κB、MAPK和JAK-STAT等炎症信号通路和炎症基因的表达发挥抑炎作用。AMPK参与调控多种慢性炎症性疾病,如炎症性肠病、非酒精性脂肪性肝等,对AMPK调控炎症机制的研究将为炎症性疾病的治疗提供新思路。本文就近年来关于AMPK调控慢性炎症性疾病及其机制的研究进展作一简要综述。
AMP-activated protein kinase (AMPK) is a highly conserved serine / threonine protein kinase, which is an energy receptor in eukaryotic cells. Studies have shown that: AMPK can inhibit the expression of inflammatory signal pathway and inflammatory genes such as NF-κB, MAPK and JAK-STAT to exert anti-inflammatory effect. AMPK is involved in the regulation of a variety of chronic inflammatory diseases such as inflammatory bowel disease and non-alcoholic fatty liver. The study on the mechanism of AMPK regulating inflammation will provide new ideas for the treatment of inflammatory diseases. This review summarizes recent advances in AMPK regulation of chronic inflammatory diseases and their mechanisms.