越来越多的证据表明小分子干扰RNA(siRNA)可促使哺乳动物细胞中的特定基因沉默。近来,一系列对致病基因有高度特异性的siRNA被发现和开发出来。来自日本德岛大学健康生命科学研究所口腔正畸学和颌面矫形学教研室的EijiTanaka教授及其领导的研究小组发现,利用siRNA技术对骨骼肌生长的负性调控剂——筒箭毒碱(myostatin,Mst)的基因进行沉默,可改善肌肉萎缩症状,为相关疾病的治疗提供了新思路。 There is growing evidence that small interfering RNAs (siRNAs) contribute to the silencing of specific genes in mammalian cells. Recently, a series of siRNAs with high specificity for pathogenic genes were discovered and developed. Professor Eiji Tanaka and his team from the Department of Orthodontics and Orthodontics at the Institute of Health and Life Sciences, Tokushima University, Japan, found that the negative regulator of skeletal muscle, siRNA, is myostatin (myostatin myostatin, Mst) gene silencing can improve the symptoms of muscular dystrophy, which provides a new idea for the treatment of related diseases.