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本文搜集了《MEDLINE》光盘上1990～1999年所记录的非甾体类抗雄性激素药物氟他胺和比卡鲁胺引起的肝损害病例,及本院发生的肝损害致肝肾衰竭致死病例,介绍了此两药在各国发生肝损害的情况及该国对此采取的措施,详细阐述了其发生肝损害的临床表现、发生机制、防范措施和治疗方法,特别强调了美国FDA以及日本化药公司、美国Sching-Plough公司对上述两药导致肝损害发出的警告。为此建议严重肝功能损害患者禁用氟他胺和比卡鲁胺,对肝功能不全或有肝病史患者应慎用或权衡利弊,其他患者用药过程中应定期监测肝功能,至少每月1次。
This article collected the MEDLINE CD-ROM from 1990 to 1999 recorded non-steroidal anti-androgen drugs flutamide and bicalutamide-induced liver damage cases, and our hospital liver damage caused by liver and kidney failure death cases , Introduced the two drugs in the occurrence of liver damage in various countries and the measures taken by the country to elaborate on the occurrence of liver damage in its clinical manifestations, mechanisms, preventive measures and treatment methods, with particular emphasis on the US FDA and Japan Drug companies, the United States Sching-Plow company issued a warning of the two drugs lead to liver damage. To this end suggest that patients with severe hepatic impairment should be disabled in patients with flutamide and bicalutamide, liver dysfunction or history of liver disease should be used with caution or weighing the pros and cons, other patients should be monitored during the regular use of drugs liver function, at least once a month .