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肺癌干细胞是来源于肺癌具有自我更新及多向分化潜能的一部分细胞群,被认为是肺癌发生发展的根源,其在肺癌转移过程中扮演重要角色,可能的作用机制主要包括上皮间质转化、肿瘤微环境、肿瘤血管生成、肿瘤耐药性、信号转导通路等几个方面。本文将对肺癌干细胞与肺癌转移相关机制做进一步探索,以期为防治肺癌转移提供新策略。
Lung cancer stem cells are derived from lung cancer cells with self-renewal and multi-directional differentiation potential part of the cell population, is considered to be the source of lung cancer development and development, which plays an important role in the process of lung cancer metastasis, possible mechanisms include epithelial mesenchymal transition, Microenvironment, tumor angiogenesis, tumor drug resistance, signal transduction pathways and so on. This article will further explore the mechanism of lung cancer stem cells and lung cancer metastasis in order to provide a new strategy for the prevention and treatment of lung cancer metastasis.