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目的:贺苏(7.2%氯化钠/6%羟乙基淀粉200/0.5注射液)用于创伤失血性休克的有效性与安全性。方法:48例急诊创伤性失血性休克患者随机分成7.2%氯化钠/6%羟乙基淀粉200/0.5注射液复苏组(实验组24例)和0.9%氯化钠/6%羟乙基淀粉200/0.5注射液复苏组(对照组24例),观察记录两组按4ml/kg初次复苏后30min内血流动力学变化,检测复苏前和观察终点时血常规、凝血功能、肝、肾功能、电解质指标,分析比较两组疗效(血压、休克指数)和安全性(血常规、凝血功能及生化指标变化)。结果:2组复苏后血压均明显升高,同时休克指数也均显著下降;实验组血压上升幅度及休克指数下降程度大于对照组;2组初次复苏后30min,红细胞(RBC)、血小板(PLAT)、血红蛋白(HB)、红细胞比积(HCT)均下降,凝血酶原时间(PT)、部分凝血活酶时间(KPTT)时间均延长,但其变化于2组间无显著差异;除实验组复苏后血CL轻度升高外,2组肝肾功能等生化指标于复苏前后均无显著变化。结论:贺苏(7.2%氯化钠/6%羟乙基淀粉200/0.5注射液)对低血容量性低血压复苏效率高,对于内环境无显著影响,可安全用于创伤失血性休克的救治。
Objective: He Su (7.2% sodium chloride / 6% hydroxyethyl starch 200 / 0.5 injection) for traumatic hemorrhagic shock efficacy and safety. Methods: Forty-eight patients with traumatic hemorrhagic shock were randomly divided into 7.2% sodium chloride / 6% hydroxyethyl starch 200 / 0.5 injection recovery group (experimental group 24 cases) and 0.9% sodium chloride / 6% hydroxyethyl Hemodynamic changes within 30 min after initial recovery of 4 ml / kg were observed and recorded in the resuscitation group (control group, 24 cases) with starch 200 / 0.5 injection. The blood routine, blood coagulation, liver and kidney Function and electrolytes. The curative effect (blood pressure, shock index) and safety (blood routine, coagulation function and biochemical index) of two groups were analyzed and compared. Results: After the resuscitation, the blood pressure was significantly increased and the shock index was also significantly decreased. The increase of blood pressure and the degree of shock index in the experimental group decreased more than that of the control group. The levels of erythrocyte (RBC), platelet (PLAT) , Hemoglobin (HB) and hematocrit (HCT), prolonged PT, and KPTT, but there was no significant difference between the two groups. In addition to the experimental group resuscitation After blood CL mildly elevated, two groups of biochemical indicators such as liver and kidney function before and after the resuscitation no significant change. Conclusion: He Su (7.2% sodium chloride / 6% hydroxyethyl starch 200 / 0.5 injection) is effective in resuscitation of hypovolemic hypotension with no significant effect on the internal environment and can be safely used in traumatic hemorrhagic shock Treatment.