在发达国家中,单纯疱疹病毒1型(HSV-1)所致的病毒性角膜炎是失明的主要病因。HSV-1的原发性感染通常是在口腔黏膜,由于机体产生特异性免疫,大部分病毒被清除。但少量病毒潜伏于三叉神经节内,在某些诱因的作用下,潜伏的病毒又可被重新激活,沿感觉神经到达皮肤、角膜等部位,形成显性感染。动物实验显示,经角膜感染HSV-1的小鼠, Viral keratitis caused by herpes simplex virus type 1 (HSV-1) is a leading cause of blindness in developed countries. The primary infection of HSV-1 is usually in the oral mucosa, where most of the virus is cleared due to the body’s specific immunity. However, a small amount of virus lurks in the trigeminal ganglion, under the action of some incentives, the latent virus can be reactivated and reach the skin and cornea along the sensory nerve to form a dominant infection. Animal experiments show that HSV-1 infected mice cornea,