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目的：研究β受体拮抗剂普萘洛尔对急性心肌梗塞的治疗作用。方法：观察对照组和普萘洛尔治疗组在左冠状动脉前降支结扎后心肌梗塞面积、血中肌酸激酶和乳酸脱氢酶的变化及外周血淋巴细胞β受体密度和亲和力的变化。结果：普萘洛尔治疗组心肌梗塞面积占心室湿重比为１５．３％，而对照组梗塞面积占心室湿重比为２８．５％。同时普萘洛尔治疗组的肌酸激酶和乳酸脱氢酶也显著低于对照组。冠状动脉结扎前外周血淋巴细胞β受体数量和亲和力分别为８５６．５６±３６．８ｆｍｏｌ／１０７细胞和６．６３±０．５２ｎｍｏｌ／Ｌ；而结扎后生理盐水组两者分别为１０６２．５±４１．４ｆｍｏｌ／１０７细胞和１０．３８±０．６１ｎｍｏｌ／Ｌ。普萘洛尔组分别为１４４５．８±４９．３ｆｍｏｌ／１０７细胞和１２．３１±１．０４ｎｍｏｌ／Ｌ。结论：普萘洛尔治疗急性心肌梗塞可以减少心肌细胞坏死数量，使心肌梗塞面积缩小。同时可以使其交感神经兴奋性降低，减慢心率，减少心律失常和心力衰竭的发生率。
Objective: To study the therapeutic effect of β-adrenoceptor propranolol on acute myocardial infarction. Methods: The changes of myocardial infarct size, blood creatine kinase and lactate dehydrogenase and the changes of β receptor density and affinity of peripheral blood lymphocytes were observed in the control group and propranolol group . Results: Propofol had a myocardial infarction area of 15.3% in the infarcted area and 28.5% of the infarcted area in the control group. Meanwhile, creatine kinase and lactate dehydrogenase in propranolol group were also significantly lower than those in control group. The number and affinity of beta receptors in peripheral blood lymphocytes before coronary artery occlusion were 856.56 ± 36.8 fmol / 107 cells and 6.63 ± 0.52 nmol / L respectively, while those in the ligation group were 1062.5 ± 41.4 fmol / 107 cells and 10.38 ± 0.61 nmol / L. The propranolol group was 1445.8 ± 49.3 fmol / 107 cells and 12.31 ± 1.04 nmol / L, respectively. Conclusion: Propranolol treatment of acute myocardial infarction can reduce the number of myocardial necrosis, myocardial infarction area reduced. At the same time can reduce the sympathetic excitement, slow down the heart rate and reduce the incidence of arrhythmia and heart failure.