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本文对14名月经规则有排卵的妇女(正常组)及7名下丘脑性闭经患者(闭经组)研究了血浆褪黑素浓度昼夜波动节律及其与血浆泌乳素(PRL)节律的关系。正常组在早卵泡期(EF)、围排卵期(PO)及黄体中期(ML)共研究三次。每次各自下午1时起每2小时取血1次共24小时。夜间11时至次晨7时卧室保持黑暗,夜间取血不影响睡眠。闭经组按同法取样1昼夜。以放射免疫法测定血浆褪黑素及PRL浓度。结果:所有正常妇女血浆褪黑素浓度显示昼夜节律:日间<5～25ng/ml;夜间9时起上升,午夜3时达峰值83±8pg/ml((?)±SE)。个体之间峰值变异很大,但EF、PO及ML褪黑素波动图形
In this paper, we studied the circadian rhythm of plasma melatonin concentration and its relationship with plasma prolactin (PRL) rhythm in 14 women with ovulation during menstruation (normal group) and 7 patients with amenorrhea (menopause group). Normal group in the early follicular phase (EF), ovulation period (PO) and mid-luteal phase (ML) were studied three times. Blood samples were collected every 2 hours for a total of 24 hours each at 1 pm each time. 11 o’clock in the evening to 7 o’clock bedroom to keep dark, night blood does not affect sleep. Amenorrhea group sampling by the same law 1 day and night. Plasma concentrations of melatonin and PRL were determined by radioimmunoassay. RESULTS: The plasma melatonin concentrations in all normal women showed a circadian rhythm: <5-25 ng / ml during the day, rising from 9:00 at night and 83 + 8 pg / ml (SE ± SE) at 3:00 midnight. Peak variability among individuals is large, but fluctuations in melatonin of EF, PO and ML are shown