目的 :探讨食管腔内渗疗的机制及其临床意义。方法 :用 5 131I尿嘧啶作为示踪剂 ,对 2 6例食管癌患者进行了临床渗透治疗的研究。结果 :经渗疗器渗透的抗癌药物除部分被肿瘤组织吸收外 ,还进入体循环 ;肿瘤及癌旁淋巴结中的T/N、L/N比值高 ,循环中抗癌药物浓度低。结论 :食管腔内渗疗是部分中晚期食管癌患者有效的治疗方法 Objective: To explore the mechanism and clinical significance of esophageal intraluminal osmotic therapy. Methods: The clinical permeation therapy was performed on 26 patients with esophageal cancer using 5 131I uracil as a tracer. RESULTS: The anti-cancer drugs penetrated by the osmotic device were partially absorbed by the tumor tissues and also entered the systemic circulation. The T/N and L/N ratios in the tumor and adjacent lymph nodes were high, and the concentration of anticancer drugs in the circulation was low. Conclusion :Esophageal cavity osmotic therapy is an effective treatment for some patients with advanced esophageal cancer