B群链球菌 ( GBS)是感染新生儿和其母亲的常见病原体 ,其中约 1 5 %的侵袭性 GBS病是由 型 GBS荚膜多糖 ( CPS)引起的。在研制预防 GBS感染的多价疫苗过程中 ,发现各型 GBS CPS与破伤风类毒素 ( TT)偶联能增强疫苗的免疫原性。本文评估了 CPS-TT结合疫苗在健康妇女中的安全 Group B Streptococcus (GBS) is a common cause of infection in newborns and their mothers, with about 15% of invasive GBS disease caused by GBS capsular polysaccharide (CPS). In the development of multivalent vaccines to prevent GBS infection, it was found that conjugation of various GBS CPSs to tetanus toxoid (TT) enhances the immunogenicity of the vaccine. This article assesses the safety of CPS-TT conjugate vaccines in healthy women