二甲基亚硝胺是一种具有急性毒性和慢性效应的化合物。给正常成年大鼠一次亚致死剂量的二甲基亚硝胺后,不能证明对肝脏的致癌性。但一次剂量给部分肝切除后的成年或新生大鼠,可以诱发肝细胞肝癌。人类慢性接触二甲基亚硝胺10个月后引起了肝硬变,但在这些病人中没有观察到肝脏的恶性变。本文报道一例慢性接触二甲基亚硝胺(32个月)患者的临 Dimethylnitrosamine is a compound with acute toxicity and chronic effects. Sub-lethal doses of dimethylnitrosamines to normal adult rats do not demonstrate liver carcinogenicity. However, hepatoma can be induced by a single dose in adult or neonatal rats after partial hepatectomy. Human chronic exposure to dimethylnitrosamine caused liver cirrhosis after 10 months, but no malignant transformation of the liver was observed in these patients. This article reports the case of a patient with chronic exposure to dimethylnitrosamine (32 months)