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大片段DNA序列的结构变异(structural variation,简称SV)包括插入/缺失、拷贝数变化和倒位等多种类型,可引起许多人类疾病(如自闭症和精神分裂症)的发生,在植物中也有关于结构变异引起农艺性状(如叶子大小和果实形状)改变的少量报道。研究人员在黄瓜全基因组变异图谱的基础上,深入开展了黄瓜SV的鉴定和分析工作,鉴定了近2.7万个SV位点,涉及约1 200万个碱基,影响近1 700个基因的功能,并揭示
Structural variations (SVs) of large DNA sequences include insertions / deletions, changes in copy number and inversions, which can cause many human diseases such as autism and schizophrenia. In plant There are also few reports of changes in agronomic traits (such as leaf size and fruit shape) caused by structural variations. Based on the genome-wide variation map of cucumber, the researchers conducted in-depth identification and analysis of SV in cucumber and identified nearly 27,000 SV sites involving about 12 million bases, affecting the function of nearly 1 700 genes And reveal