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众所周知,种种辐射的生物效应(皮肤红斑、动物死亡、染色体畸变、培养细胞的克隆形成能力)都随剂量率的降低而减少。这些效应的一种解释是生物体系中存在着修复的机制。我们用模式脂膜(脂质体)所做的研究曾经证明,多聚不饱和脂肪酸的损伤(脂类的过氧化)与剂量率呈反比。这种效应已经用脂类双层膜上发生缓慢发展的链式反应来解释。如同在测定相应生物学终点能得出明确的结论那样,现在可以应用对辐射的剂量率反比效应作为膜损伤的指标。本文考虑了以下两个生物学终点的剂量率效应:1,完整红细胞中钾和血红蛋白(Hb)的丧失;2,淋巴细胞对苔酚兰的排斥作用。从牛血中分离得到的红细胞,接受0.05～30戈瑞X线照射,其剂量率为0.0013～10戈瑞/分。牛淋巴细
It is well known that the biological effects of various radiations (erythema of the skin, animal death, chromosomal aberrations, clonogenic capacity of cultured cells) decrease with dose rate reduction. One explanation for these effects is that there is a mechanism of repair in the biological system. Our studies with model lipid membranes (liposomes) have shown that polyunsaturated fatty acid damage (lipid peroxidation) is inversely proportional to the dose rate. This effect has been explained by the slowly developing chain reaction taking place on lipid bilayer membranes. As can be clearly concluded from the determination of the corresponding biological end point, it is now possible to apply the inverse ratio effect of dose rate to radiation as an indicator of membrane damage. This article considers the dose-rate effects of two endpoints of biology: loss of potassium and hemoglobin (Hb) in intact red blood cells, and rejection of moxifloran by lymphocytes. Erythrocytes isolated from bovine blood, receiving 0.05 to 30 Gy X-ray irradiation, the dose rate of 0.0013 to 10 Gy / min. Lean lymphocytes