目的:验证刺五加皂甙、水飞蓟素和红景天皂甙对运动训练大鼠糖原合成的作用,观察其对大鼠运动能力和生长发育的影响。方法:72只雄性SD大鼠被随机分为6组:安静对照组、训练对照组、训练+小剂量刺五加皂甙(250mg·kg-1·d-1)组、训练+大剂量刺五加皂甙(500mg·kg-1.d-1)组、训练+红景天皂甙(500mg·kg-1·d-1)组和训练+水飞蓟素(50mg·kg-1·d-1)组,各给药组每天训练后30～40min分别给予相应药物灌胃,在给药的同时,给予蔗糖水溶液2g·kg-1·d-1;安静对照组和训练对照组同时给予等体积的含等量蔗糖的水溶液。训练组大鼠完成6天负重2%的递增负荷游泳训练,各组大鼠休息3天后,训练组大鼠负重3%游泳至力竭,记录各训练组大鼠力竭时间。休息4天后,各训练组大鼠最后完成5天负重3%的游泳训练,末次训练后22小时内处死全部大鼠,并测定相关指标。结果:(1)与训练对照组比较,除红景天皂甙组实验后体重显著降低外,其它用药组在各项形态指标(身长、体重、肥胖评定指数、附睾周围脂肪垫重量等)上均无显著差异;(2)红景天皂甙组和大剂量刺五加皂甙组游泳至力竭的时间显著长于训练对照组;(3)大剂量刺五加皂甙组的比目鱼肌糖原和肝糖原含量都显著高于训练对照组,小剂量刺五加皂甙组肝糖原含量与运动训练组相比虽有升高趋势但无显著差异;红景天皂甙组和水飞蓟素组的糖原含量与训练对照组无显著差异。结论:刺五加皂甙和红景天皂甙有利于提高大鼠运动能力,提示刺五加和红景天中的皂甙类化合物可能是其抗运动性疲劳功能的有效成分。刺五加皂甙能提高训练大鼠肌糖原和肝糖原水平,但有剂量依赖性,这可能是它提高运动耐力的机制之一。 Objective: To verify the effects of Acanthopanax senticosus, silymarin and saponins of Rhodiola on glycogen synthesis in exercise training rats and observe its effects on exercise ability and growth of rats. METHODS: Seventy-two male Sprague-Dawley rats were randomly divided into 6 groups: a quiet control group, a training control group, a training + small dose of Acanthopanax Saponins (250 mg·kg-1·d-1) group, and a training + high-dose stab five. Added saponin (500mg·kg-1.d-1) group, training + saponin group (500mg·kg-1·d-1) and training + silymarin (50mg·kg-1·d-1) group, Each administration group was given intragastric administration of the corresponding drugs 30 to 40 minutes after each day of training. At the same time as the administration, an aqueous sucrose solution of 2 g·kg-1·d-1 was given. The quiet control group and the training control group were given equal volume at the same time. Aqueous sucrose solution. Rats in the training group completed 6-day weight-bearing training with 2% weight-bearing weight. After 3 days of rest in each group, the rats in the training group had 3% of weight-bearing swimming until exhaustion. The exhaustion time of each training group was recorded. After 4 days of rest, each training group completed a final 3% weight-bearing swimming training for 5 days, and all rats were sacrificed within 22 hours after the last training, and relevant indicators were measured. Results: (1) Compared with the training control group, with the exception of the weight loss of the Rhodiola Saponin group after the experiment was significantly reduced, the other drug groups were all on the morphological indicators (length, weight, obesity assessment index, weight around the epididymal fat pad, etc.) There was no significant difference; (2) Rhodiola Saponin group and large dose of Acanthopanax Saponins group had significantly longer swimming time to exhaustion than training control group; (3) Soleus muscle glycogen and glycogen in large dose Acanthopanax senticosus group The original content was significantly higher than the training control group. The content of hepatic glycogen in the small dose of Acanthopanax senticosus group had an increase trend compared with the exercise training group, but there was no significant difference; the glycogen content of the salvia miltiorrhiza group and silymarin group was similar. There was no significant difference in the training control group. Conclusion: Acanthopanax senticosus and Rhodiola saponin can improve the exercise ability of rats, suggesting that the saponins of Acanthopanax senticosus and Rhodiola rosea may be the effective components of their anti-exercise fatigue function. Acanthopanax senticosus can increase the levels of muscle glycogen and hepatic glycogen in trained rats, but it is dose-dependent, which may be one of the mechanisms for improving exercise endurance.