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目的:评估上转换发光技术侧流免疫夹心法(UCP-LFA)检测PGL-I抗体对麻风接触者发病风险预测的价值.方法:采用UCP-LFA方法检测贵州59例麻风患者、87例家庭接触者和55例健康对照者的PGL-I抗体水平.结果:麻风患者中PGL-I抗体阳性率为81.4％、麻风接触者为5.7％、健康对照人群为1.8％,差异有统计学意义(P<0.005).少菌型和多菌型PGL-I抗体阳性率分别为45.5％和89.4％,差异有统计学意义(P<0.005).BI阳性和BI阴性患者的PGL-I抗体阳性率分别为83％和0％,差异有统计学意义(P<0.005).结论:PGL-I IgM抗体水平对麻风发病风险有一定的预测作用.“,”Objective:To evaluate the value of lateral flow immuno-sandwich assay using up-converting phosphor reporter particles ( UCP-LFA) in predicting the risk of leprosy contacts by detecting PGL-I antibod-y. Methods:The PGL-I IgM levels were measured by UCP-LFA in 59 leprosy patients, 87 household con-tacts and 55 healthy controls in Guizhou. Results:The positivity rates of anti-PGL-I IgM in leprosy patients, household contacts and healthy controls were 81. 4％, 5. 7％ and 1. 8％, with significant differences between them ( P<0. 005 ) . The positivity rates of anti-PGL-I IgM in patients with paucibacillary ( PB ) and multibacillary leprosy ( MB) were 45.5％ and 89.4％, with a significant difference ( P<0.005) . The positivity rates of anti-PGL-I IgM in the patients with BI+and BI-were 83％ and 0％, with a significant difference ( P<0.005) . Conclusion:PGL-I IgM antibody can predict the risk of leprosy.