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目的:了解兰索拉唑对哮喘病人应用糖皮质激素治疗所致的胃肠道不良反应的预防效果.方法:选择住院应用糖皮质激素治疗的哮喘病人58例,在应用糖皮质激素治疗的同时,治疗组20例口服兰索拉唑30MG,每晚1次;对照1组13例口服H2受体阻滞药雷尼替丁150MG或西咪替丁400MG,每日2次;对照2组25例口服安慰剂肌苷200MG,每日3次.随诊共3个月,观察病人有无出现胃肠道不良反应.结果:治疗组、对照1组、对照2组的消化道症状发生率分别为10％、69％、44％,治疗组分别与后两组比较,P＜0.01;治疗组、对照1组、对照2组的上消化道出血发生率分别为0、23％、24％,治疗组分别与后两组比较,P＜0.01.结论:兰索拉唑30MG,每晚1次口服可明显降低应用糖皮质激素治疗的哮喘病人的胃肠道不良反应的发生率,并优于口服雷尼替丁或西咪替丁及安慰剂“,”Objective:To study the effects of lansoprazole on the prevention of gastrointestinal adverse reactions induced by glucocorticoids(GC)in asthmatic patients Methods:58 hospitalized patients with asthma treated with GC were divided into three groups In lansoprazole(L)group,20 patients were treated with lansoprazole 30 mg once every night In control group 1,13 patients were treated with ranitidine 150 mg or cimetidine 400 mg twice daily In control grou...