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目的:探讨腹膜后脂肪肉瘤(RPLS)的诊疗经验,并寻找影响RPLS术后复发的因素。方法:收集并回顾性分析84例RPLS病人临床病理特征、外科处理方法及影响术后复发的因素。结果:84例病人共行手术110例次,肿瘤完全切除72例次(65.5%),联合周围脏器切除66例次(60.0%)。术后总复发率64.3%,中位复发时间10个月。多因素分析显示RPLS分化程度和肉眼完全切除是影响术后复发的独立因素。联合脏器切除组与单纯肿瘤切除组的肉眼完全切除率分别为72.7%、54.5%,差异有统计学意义(P<0.05)。结论:RPLS术后复发率高,肿瘤分化程度和肉眼完全切除是影响RPLS术后复发时间的独立因素。联合周围脏器的肿瘤切除可明显提高肿瘤的完全切除率。
Objective: To explore the diagnosis and treatment of retroperitoneal liposarcoma (RPLS) and to find out the factors influencing the recurrence of RPLS. Methods: The clinicopathological characteristics, surgical treatment and the factors affecting postoperative recurrence were collected and retrospectively analyzed in 84 patients with RPLS. Results: A total of 110 patients underwent total resection in 84 patients. Tumor resection was performed in 72 cases (65.5%) and combined with surrounding organs in 66 cases (60.0%). The total postoperative recurrence rate was 64.3%, the median recurrence time was 10 months. Multivariate analysis showed that RPLS differentiation and macroscopic resection were independent factors that affected the postoperative recurrence. Macroscopic resection rates of combined visceral resection and simple resection were 72.7% and 54.5%, respectively, with significant differences (P <0.05). Conclusion: The high recurrence rate of RPLS, the degree of tumor differentiation and complete resection of the macroscopic eye are the independent factors influencing the recurrence time after RPLS. Tumor resection of the surrounding organs can significantly improve the complete resection rate of the tumor.