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目的:探讨乳腺专用PET的临床应用价值。方法:选取76例于本院行18F-FDG PET/CT检查发现乳腺病灶,或临床疑有隐匿性乳腺癌行18F-FDG PET/CT检查的患者,在知情同意下进行乳腺专用PET复查,测定最大标准摄取值(SUVmax)。采用独立样本t检验比较不同病灶大小、超声分级、分子亚型之间SUVmax的差异。结果:最终获得病理并纳入分析48例,专用PET检出病灶63个,最小病灶约0.3 cm。恶性病灶长径<1 cm、1~2 cm和>2 cm时,SUVmax平均值分别为4.58±2.01、7.51±3.10和11.27±5.29,两两比较差异均有统计学意义(P<0.01或P<0.05);乳腺影像报告和数据系统(BI-RADS)4级与5级之间SUVmax差异也有统计学意义(P<0.05);各分子亚型之间SUVmax差异无统计学意义。结论:乳腺专用PET对探测乳腺小病灶、多中心、多原发病灶具有很好的临床应用价值。
Objective: To investigate the clinical value of breast-specific PET. Methods: A total of 76 patients underwent 18F-FDG PET / CT examination in our hospital or 18F-FDG PET / CT patients with clinically suspected occult breast cancer were enrolled in this study. The maximum standard intake (SUVmax). Independent samples t test was used to compare the differences of SUVmax between different lesion sizes, ultrasound grading and molecular subtypes. Results: The final pathology and included in the analysis of 48 cases, 63 PET-specific detection, the smallest lesions of about 0.3 cm. The average values of SUVmax for malignant lesions were 4.58 ± 2.01, 7.51 ± 3.10 and 11.27 ± 5.29, respectively, with long diameters <1 cm, 1 ~ 2 cm and> 2 cm, with significant differences in any pairwise comparison (P <0.01 or P <0.05). There was also a statistically significant difference in SUVmax between the 4th and 5th breast biopsy (BI-RADS) (P <0.05). There was no significant difference in SUVmax among the various molecular subtypes. Conclusion: Breast PET has good clinical value in detecting small lesions, multiple centers and multiple primary lesions.