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目的分析沙美特罗替卡松联合阿奇霉素作用于儿童哮喘治疗中的应用效果。方法 50例哮喘患儿,采用数字随机法将患儿分为观察组和对照组,每组25例。两组患儿均接受沙美特罗替卡松治疗,观察组在此基础上联合应用阿奇霉素。比较两组患儿疗效、治疗后肺功能指标及疾病复发率。结果观察组患儿治疗总有效率为96%,高于对照组的76%,差异具有统计学意义(P<0.05)。治疗后,观察组患儿用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、呼气峰值流速(PEF)均优于对照组,差异具有统计学意义(P<0.05)。观察组疾病复发率为4.00%(1/25);对照组疾病复发率为24.00%(6/25),观察组患儿疾病复发率低于对照组,差异具有统计学意义(χ~2=4.3716,P<0.05)。结论在儿童哮喘的治疗中,将沙美特罗替卡松与阿奇霉素联合应用具有较好的临床效果,方法经验证效果确切,值得在临床中借鉴。
Objective To analyze the effect of salmeterol and fluticasone combined with azithromycin in the treatment of childhood asthma. Methods Fifty children with asthma were randomly divided into observation group and control group with 25 cases in each group. Two groups of children were treated with salmeterol and fluticasone treatment, the observation group on the basis of this combination of azithromycin. The curative effect of the two groups were compared, the index of pulmonary function and the rate of disease recurrence after treatment. Results The total effective rate of treatment group was 96% in observation group, which was higher than 76% in control group, the difference was statistically significant (P <0.05). After treatment, FVC, FEV1 and PEF in observation group were better than those in control group, and the difference was statistically significant (P <0.05). The recurrence rate was 4.00% (1/25) in observation group and 24.00% (6/25) in control group. The recurrence rate of disease in observation group was lower than that in control group (χ ~ 2 = 4.3716, P <0.05). Conclusions In the treatment of asthma in children, the combination of salmeterol and triclosan with azithromycin has a good clinical effect. The method has been proved to be effective and worthy of reference in clinical practice.