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目的探讨雌激素受体表达与食管鳞状细胞癌临床病理的关系。方法用免疫组织化学方法检测了47例林县食管癌组织中ER的表达。结果47例食管癌标本中，ER阳性者19例，其表达率为40．4％（19／47）；生存期大于5年组与小于5年组相比，ER阳性率为28．6％和57．9％，具有显著性差异（P＜0．05），与性别、癌组织分化程度及有无淋巴结转移无关。结论食管癌可能是雌激素依赖性肿瘤，雌激素受体阳性的食管癌与雌激素受体阴性的食管癌相比，后者的预后较好。
Objective To investigate the relationship between estrogen receptor expression and clinicopathology of esophageal squamous cell carcinoma. Methods Immunohistochemistry was used to detect the expression of ER in 47 cases of esophageal cancer in Lin county. Results Of the 47 esophageal cancer specimens, 19 were positive for ER, and the expression rate was 40.4% (19/47). The survival rate was greater than 5 years and the ER positive rate was 28.6% compared with the group less than 5 years. There was a significant difference (P<0.05) with 57.9%, which was not related to gender, degree of differentiation of cancerous tissue, and lymph node metastasis. Conclusions Esophageal cancer may be an estrogen-dependent tumor. Estrogen receptor-positive esophageal cancer has a better prognosis than estrogen receptor-negative esophageal cancer.