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雌激素刺激妇科肿瘤发生主要与雌激素及其代谢中产物儿茶酚雌酮在人体的积聚有关,儿茶酚O-甲基转移酶(catachol O-m ethyltransferase,COMT)可将儿茶酚雌酮甲基化为可溶于水的代谢产物排出体外,COMT具有基因多态性,显示不同的活性,因而决定不同的儿茶酚雌酮的分解速度,在与雌激素刺激有关的乳腺癌、卵巢癌、子宫内膜癌等妇科肿瘤的发病过程中起到重要的作用。现将COMT基因多态性和雌激素代谢与妇科肿瘤发生风险关系的研究进展作一综述。
Estrogen stimulating gynecologic oncology is mainly related to the accumulation of estrogen and its metabolite catechol estrone in the human body. Catechol O-methyltransferase (COMT) As the water-soluble metabolites are excreted into the body, COMT has genetic polymorphisms that show different activities and thus determine the rate of catechol estrone dissociation in estrogen-stimulated breast, ovarian , Endometrial cancer and other gynecological tumors play an important role in the pathogenesis. Now COMT gene polymorphism and estrogen metabolism and gynecologic oncology risk of research progress are reviewed.