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卡波氏肉瘤相关疱疹病毒(KSHV)可导致人类产生卡波氏肉瘤(KS),即AIDS病人最为常见的肿瘤。广泛的流行病学研究显示,KSHV的流行与KS相似并呈现明显的地域分布型。为调查KSHV在汉族普通人群中的感染情况,我们以KSHVORF65编码的小衣壳蛋白(smallcapsidprotein)为抗原,采用酶联免疫(ELISA)分析方法,对湖北地区560例汉族普通人群血清样品进行了KSHV抗体检测。在检测的560份血样中,KSHV抗体总阳性率为5.2%,其中,男性阳性率为5.7%,女性为4.5%。统计学分析显示,KSHV感染率在男女性别上无差异(P=0.542),但与年龄有一定的相关性:10岁以下儿童群体较之10岁以上人群KSHV感染率具有显著的统计学差异(P=0.006,OR=6.692,95%CI=1.710-26.198);60岁以上的老年人群KSHV感染率有上升趋势,但无统计学明显差异(P=0.052)。上述结果表明,KSHV在这一地区的流行与西方成年人群的感染率相似,但在儿童群体中的相对较高的感染率与一些非洲地区的接近。由此提示在该群体可能存在特殊的传播模式。
Kaposi’s sarcoma-associated herpes virus (KSHV) causes the generation of Kaposi’s sarcoma (KS) in humans, the most common tumor in AIDS patients. Extensive epidemiological studies have shown that the prevalence of KSHV is similar to KS and shows a pronounced geographical distribution. To investigate the prevalence of KSHV infection in the general population of Han Chinese, KSHVORF65-encoded small capsid protein was used as an antigen. ELISA was used to detect KSHV in 560 Han general population from Hubei Province. Antibody detection. Among the 560 blood samples tested, the total positive rate of KSHV antibody was 5.2%, of which, the positive rate was 5.7% in males and 4.5% in females. Statistical analysis showed that there was no difference in KSHV prevalence between men and women (P = 0.542), but with age-related associations: KSHV prevalence was significantly different among children under 10 years of age compared with those over 10 years of age P = 0.006, OR = 6.692, 95% CI = 1.710-26.198). KSHV prevalence rate in elderly people over the age of 60 has an increasing trend, but no statistically significant difference (P = 0.052). The above results indicate that the prevalence of KSHV in this area is similar to that of western adult populations, but the relatively high prevalence among children is similar to that of some African regions. This suggests that there may be special modes of transmission in this group.