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目的通过对照研究观察血清可溶性细胞间黏附分子-1(sICAM-1)和白细胞介素-17A(IL-17A)在小儿肺炎支原体(MP)肺炎(MPP)伴喘息患儿中的表达及临床意义。方法以甘肃医学院附属医院2015年6月-2016年6月间收治的支气管肺炎患儿112例为研究对象,根据病况不同分为MPP伴喘息组(30例),MPP无喘息组(46例),非MPP组(36例),并以健康体检儿童30例为对照组。采用ELISA检测各组血清sICAM-1和IL-17A水平,采用化学发光免疫分析法检测血清总免疫球蛋白(TIg E)水平。结果 MPP伴喘息组、MPP无喘息组的sICAM-1水平显著高于非MPP组;在MPP患儿中,MPP伴喘息组血清sICAM-1水平高于MPP无喘息组(P<0.05);MPP伴喘息组、MPP无喘息组、非MPP组IL-17A水平均较正常对照组升高(P<0.05)。结论 sICAM-1在MPP患儿尤其是伴喘息患儿血清中水平明显升高,且MPP伴喘息患儿血清sICAM-1水平与TIg E呈正相关关系,提示sICAM-1可能在MPP伴喘息患儿的病程中起着重要作用。
Objective To observe the expression and clinical significance of serum soluble intercellular adhesion molecule-1 (sICAM-1) and interleukin-17A (IL-17A) in children with mycoplasma pneumoniae (MPP) . Methods One hundred and twelve children with bronchial pneumonia admitted from June 2015 to June 2016 in Gansu Medical College Affiliated Hospital were enrolled in this study. The patients were divided into MPP with asthma group (30 cases), MPP without asthma group (46 cases ), Non-MPP group (36 cases), and healthy children 30 cases as control group. Serum levels of sICAM-1 and IL-17A in each group were detected by ELISA. Total immunoglobulin (TIgE) levels were measured by chemiluminescence immunoassay. Results The levels of sICAM-1 in MPP with wheezing group and MPP without wheezing group were significantly higher than those in non-MPP group. The level of sICAM-1 in MPP with wheezing group was higher than that in MPP without wheezing group (P <0.05) The levels of IL-17A in the asthmatic group, MPP without asthmatic group and non-MPP group were higher than those in the normal control group (P <0.05). Conclusion The level of serum sICAM-1 in children with MPP especially with wheezing is significantly higher than that in children with MPP, and there is a positive correlation between sICAM-1 and TIg E in MPP with wheezing, suggesting that sICAM-1 may be associated with wheezing The course of the disease plays an important role.