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目的 比较ⅠA和ⅠB期非小细胞肺癌 (NSCLC)患者术后远期生存率的差异 ,分析影响Ⅰ期NSCLC患者术后远期生存率的因素。方法 回顾性分析我科在 1 974～ 1 995年期间手术治疗的 96例Ⅰ期NSCLC病例 ,对患者的性别、年龄、T分级、原发肿瘤大小、脏层胸膜侵犯、切除方式、肿瘤病理类型、分化程度和位置共 9个可能影响术后远期生存率的因素进行了单因素和多因素分析。结果 ⅠA和ⅠB期NSCLC患者术后 5年生存率有显著性差异 (P <0 .0 5 ) ,单因素分析提示T分级、原发肿瘤大小、脏层胸膜侵犯、肿瘤分化程度对Ⅰ期NSCLC患者术后 5年生存率有显著性影响 (P <0 .0 5 ) ,但多因素分析提示只有脏层胸膜侵犯和肿瘤分化程度是独立预后因素 (P <0 .0 5 )。结论 Ⅰ期NSCLC可进一步分成ⅠA和ⅠB两个亚期 ,两个亚期间5年生存率存在显著性差异 ,脏层胸膜侵犯和肿瘤分化程度是影响Ⅰ期NSCLC患者术后 5年生存率的独立预后因素。
Objective To compare the long-term survival of patients with stage I and stage I non-small cell lung cancer (NSCLC) and to analyze the factors influencing the long-term survival of patients with stage I NSCLC. METHODS: A retrospective analysis of 96 patients with stage I NSCLC who underwent surgical treatment in our department from 1 974 to 1 995 was performed. The patient’s gender, age, T grade, primary tumor size, visceral pleural invasion, resection method, and tumor pathology were analyzed. A total of 9 factors that may affect postoperative long-term survival were analyzed by univariate and multivariate analysis. Results The 5-year survival rate of NSCLC patients with IA and IB stage was significantly different (P < 0.05). Univariate analysis suggested that T-grade, primary tumor size, visceral pleural invasion, and tumor differentiation level in stage I NSCLC The 5-year survival rate of patients was significantly affected (P < 0.05), but multivariate analysis suggested that only visceral pleural invasion and tumor differentiation were independent prognostic factors (P <0.05). Conclusions Stage I NSCLC can be further divided into two substages: IA and IB. There is a significant difference in 5-year survival rate between the two sub-periods. Dirty pleural invasion and tumor differentiation are independent of 5-year survival rate in patients with stage I NSCLC. Prognostic factors.