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目的探讨维生素D受体(VDR)基因启动密码子FokⅠ位点多态性与泌尿系统结石的关联性。方法计算机检索PubMed、Embase、中国知网、维普中文科技期刊数据库、万方数据库,查找并筛选出研究VDR基因FokⅠ位点多态性与泌尿系结石关系的病例对照研究(case-control study),同时查阅检索结果中所附相似文献及参考文献,检索时限均为建库至2013年10月12日。由两名评价员单独进行文献筛选及资料提取,采用StataSE 12.0软件进行Meta分析及其他统计学分析。结果共纳入文献15篇,结石患者共2422例,健康人2554例。Meta分析结果显示,各模型下整体效应均无统计学意义(P>0.05),亚组分析结果显示,在印度人和伊朗人中FokⅠ位点多态性与泌尿系结石有统计学意义:等位基因模型ORIndian=1.44,95%CI(1.01,2.06),ORIran=0.32,95%CI(0.21,0.48);显性模型ORIran=0.09,95%CI(0.04,0.23);隐性模型ORIndian=2.49,95%CI(1.40,4.42),ORIran=0.46,95%CI(0.26,0.80);共显性模型下ff/FF组ORIran=0.09,95%CI(0.04,0.24),ff/Ff组ORIndian=0.43,95%CI(0.24,0.76),ORIran=0.09,95%CI(0.03,0.24);超显性模型下,ORIndian=0.36,95%CI(0.24,0.53);ORIran=0.49,95%CI(0.27,0.88)。结论 FokⅠ位点多态性可能与印度人泌尿系结石有一定相关性。还不能认为VDR基因启动密码子FokⅠ位点多态性与中国人泌尿系结石的形成存在关联性。FokⅠ位点多态性与伊朗人泌尿系结石的形成可能有关,但尚缺乏充分证据。
Objective To investigate the association between the promoter codon Fok Ⅰ polymorphism of vitamin D receptor (VDR) gene and urolithiasis. Methods PubMed, Embase, CNKI, VIP database of Chinese science and technology, Wanfang database were searched by computer. A case-control study was conducted to find out the relationship between FDRⅠ polymorphism of VDR gene and urolithiasis. At the same time access to search results attached to similar documents and references, search time are building database to October 12, 2013. Two reviewers independently screened the literature and extracted data. Meta-analysis and other statistical analyzes were performed using StataSE 12.0 software. Results A total of 15 articles were included. There were 2422 cases of stone and 2554 healthy people. Meta-analysis showed that the overall effect was not statistically significant under each model (P> 0.05). The subgroup analysis showed that the Fok I polymorphism and urinary calculi in Indians and Iranans were statistically significant: ORIndian = 1.44, 95% CI (1.01,2.06), ORIran = 0.32,95% CI (0.21,0.48); The dominant model ORIran = 0.09,95% CI (0.04,0.23); recessive model ORIndian = ORIran = 0.46, 95% CI (0.26, 0.80); ORIran = 0.09,95% CI (0.04,0.24) in ff / FF co-dominant model, ff / Ff group ORIndian = 0.43, 95% CI 0.24, 0.76, ORIran 0.09, 95% CI 0.03, 0.24; ORIndian = 0.36, 95% CI % CI (0.27, 0.88). Conclusion Fok Ⅰ polymorphism may be associated with Indian urolithiasis. It can not be considered that VDR gene promoter codon Fok Ⅰ site polymorphism and the formation of urinary tract stones in China there is a correlation. The Fok I polymorphism may be related to the formation of urolithiasis in Iran, but there is not enough evidence yet.