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正常情况下甲胎蛋白(AFP)含量于婴儿出生后数月降至<10ng/ml以致无法测定.作者将1986年Musto等的检验方法加以改进成为高出10—20倍灵敏度的放射免疫测定法,使含量很低的AFP也能得到测定。作者在美国休斯敦270例年龄16—83岁平均40.7岁的供血者检查乙肝和免疫缺陷病毒阴性而谷丙转氨酶正常者,其AFP含量为3.04ng/m1±1.9SD。男性含量与女性相比较高,具有统计学意义(P<0.004)。肝癌病例再现AFP的概率比女性多。未知雌激素对AFP有何影响。回归分析表现男性与女性的AFP含量随年龄而升高亦具有统计学意义(男P<0.05;女P<0.01)。这种所见在非洲象牙海岸也有类似情况。它归因于肝脏受黄曲霉菌
Under normal circumstances, the AFP content was reduced to <10 ng / ml in months after birth and could not be determined. The authors modified Musto et al.’s test in 1986 to be a radioimmunoassay 10 to 20 times more sensitive , So that low levels of AFP can be measured. The authors in Houston, USA, 270 patients aged 16-83 years old average 40.7-year-old donor of hepatitis B and immunodeficiency virus-negative and normal alanine aminotransferase, the AFP content of 3.04ng / m1 ± 1.9SD. The male content was higher than the female, with statistical significance (P <0.004). Liver cancer cases reproduce more AFP than women. The effect of unknown estrogen on AFP. Regression analysis showed that male and female AFP levels increased with age were also statistically significant (male P <0.05; female P <0.01). This observation is also found in the Ivory Coast of Africa. It is due to the liver infected with Aspergillus flavus