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目的对比分析左氧氟沙星与莫西沙星治疗耐多药肺结核临床疗效和药物不良反应。方法采用计算机随机分组的方式将本院收治的100例耐多药肺结核患者对照组和观察组,两组患者均给予基础抗结核药物治疗,对照组患者联合左氧氟沙星,观察组患者联合莫西沙星,比较两组患者临床疗效和用药安全性。结果观察组患者治疗总有效率为98.00%,对照组患者治疗总有效率为80.00%,差异有统计学意义(P<0.05)。两组患者在不良反应发生方面差异无统计学意义(P>0.05)。结论左氧氟沙星与莫西沙星联合基础抗结核药物治疗耐多药肺结核均取得较为满意的效果,但是,莫西沙星组患者治疗效果优于左氧氟沙星者。
Objective To compare and analyze the clinical efficacy and side effects of levofloxacin and moxifloxacin in the treatment of multidrug-resistant pulmonary tuberculosis. Methods 100 cases of MDR-TB patients in our hospital were randomly divided into control group and observation group. Both groups were given basic anti-tuberculosis drugs. Patients in the control group were treated with levofloxacin. The observation group was combined with moxifloxacin, The clinical efficacy and medication safety of the two groups were compared. Results The total effective rate was 98.00% in the observation group and 80.00% in the control group, the difference was statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Levofloxacin and moxifloxacin combined with basic anti-TB drugs in the treatment of multi-drug resistant pulmonary tuberculosis have achieved satisfactory results, however, moxifloxacin treatment group was superior to levofloxacin.