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本文对新疆地区1717例遗传咨询者进行淋巴细胞染色体核型分析,检出异常核型180例,异常核型检出率10.48%(180/1717),性染色体异常124例,占7.22%(124/1717),其中大Y 98例,小Y 2例,常染色体异常56例,占3.26%(56/1717),D、G组短臂变异36例。结论异常孕产史不但与染色体畸变有关,而且与染色体多态性也有相关性,应引起临床上的重视,对不良孕产史患者常规进行染色体检查是十分必要的。
In this paper, 1717 cases of genetic counseling Xinjiang region lymphocyte chromosome karyotype analysis, detected 180 cases of abnormal karyotype, abnormal karyotype detection rate of 10.48% (180/1717), 124 cases of sex chromosome abnormalities, accounting for 7.22% (124 / 1717), of which 98 were large Y, 2 were small Y, 56 were autosomal abnormalities, accounting for 3.26% (56/1717), and 36 were short-arm variations in D and G groups. Conclusion Abnormal history of pregnancy is not only related to chromosome aberration, but also to chromosome polymorphism, which should be paid more attention in clinic. It is necessary to perform routine chromosome examination in patients with abnormal pregnancy history.