糖尿病肾病被定义为糖尿病合并蛋白尿(尿白蛋白>30mg/24h)或肾功能损害(e GFR<60ml/min/1.73m2)或二者兼有。其金标准为肾脏活检。但应注意,诊断需除外其他可能导致肾损害的病因,例如在无糖尿病视网膜病变时e GFR快速下降,或蛋白尿快速增多需考虑有无其他导致肾脏损害的原因。糖尿病肾病现已成为终末期肾脏病的首要原因。糖尿病肾病的自然病程可分为几个阶段:初期表现为肾脏肥大和肾小球高滤过,之后可进展至微量白蛋白 Diabetic nephropathy is defined as diabetic comorbid proteinuria (urinary albumin> 30 mg / 24h) or renal dysfunction (e GFR <60 ml / min / 1.73m2) or both. The gold standard for kidney biopsy. It should be noted, however, that other causes of renal damage, such as a rapid decrease of e GFR in the absence of diabetic retinopathy or a rapid increase in proteinuria, need to be considered for any cause other than kidney damage. Diabetic nephropathy has now become the primary cause of end-stage renal disease. The natural history of diabetic nephropathy can be divided into several stages: the initial performance of renal hypertrophy and glomerular hyperfiltration, then progress to microalbumin