论文部分内容阅读
探讨早期联合用药对矽尘致大鼠肺纤维化的影响。 [方法 ]采用SD大鼠 ,低剂量石英粉尘非暴露式气管注入染尘 (2 0mg/鼠 )后 3d,在病变早期阶段开始给药 ,分别治疗 2个月和 5个月。疗效指标为肺湿重、肺胶元含量、肺总脂含量及肺内矽性病变分级。 [结果 ]以肺湿重、肺胶元含量、肺总脂为依据的综合疗效指标显示 ,各用药组都显著低于染尘对照组。肺内矽性病变分级亦有相应的差异。 [结论 ]早期联合用药对大鼠肺纤维化有一定阻断作用 ,其疗效优于各单独用药组。
To investigate the effect of early combination therapy on pulmonary fibrosis induced by silica dust in rats. [Methods] SD rats and low-dose quartz dust were exposed to the trachea (20 mg / mouse) for 3 days and then were administered in the early stage of the disease and were treated for 2 months and 5 months respectively. Efficacy indicators for lung wet weight, lung collagen content, total lipid content of the lung and grade of silicosis within the lung. [Result] The comprehensive curative indexes based on the wet weight of lung, the content of lung collagen, and the total fat of lung showed that the dosage groups were significantly lower than those of the control group. Silicosis lesions in the lung also have corresponding differences. [Conclusion] The early combination therapy can block the pulmonary fibrosis in rats, and its curative effect is better than that of the single treatment group.