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观察正常人和慢性阻塞性肺疾病患者不同时期血浆中一氧化氮 (NO)、超氧化物歧化酶 (SOD)和丙二醛 (MDA)含量的改变。结果发现慢性阻塞性肺疾病急性发作期血浆一氧化氮和超氧化物歧化酶均明显低于缓解期 (P<0 .0 5 ) ,在缓解期仍明显低于正常对照组 (P<0 .0 5 )。血浆丙二醛在慢性阻塞性肺疾病急性发作期明显高于缓解期 (P<0 .0 5 ) ,在缓解期血浆丙二醛仍明显高于正常对照组 (P<0 .0 5 )。提示慢性阻塞性肺疾病急性发作期由于患者反复感染、细菌或病毒的刺激 ,缺氧和高碳酸血症等因素 ,使肺血管内皮细胞损伤 ,抗氧化功能低下 ,导致血浆一氧化氮和超氧化物歧化酶减少、丙二醛增高。
To observe the changes of plasma levels of nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MDA) in normal and chronic obstructive pulmonary disease patients. Results The levels of plasma nitric oxide and superoxide dismutase in acute exacerbation of chronic obstructive pulmonary disease were significantly lower than those in the remission stage (P <0.05), and still significantly lower than those in the normal control group (P <0. 0 5). Plasma malondialdehyde in acute exacerbation of chronic obstructive pulmonary disease was significantly higher than that in remission (P <0.05), and plasma malondialdehyde was still significantly higher in remission than in normal control (P <0.05). Prompt chronic obstructive pulmonary disease in patients with acute exacerbation due to repeated infections, bacterial or viral stimulation, hypoxia and hypercapnia and other factors, the pulmonary vascular endothelial cell damage, anti-oxidation dysfunction, leading to plasma nitric oxide and superoxide Disulfide diminished, malondialdehyde increased.